The study suggests that cyclic GMP may not be the intracellular second messenger for the inhibitory action of ANP on aldosterone secretion in bovine adrenal cells.
Questions cGMP as ANP second messenger in bovine adrenal cells; leaves open the aldosterone signaling pathway for further study.
When bovine adrenal zona glomerulosa cells were incubated with alpha-human atrial natriuretic polypeptide (alpha-hANP), the basal aldosterone production in the cells was hardly affected, although the angiotensin II- or K+-stimulated production was completely inhibited. alpha-hANP was found to cause the generation of cyclic GMP in the cells. When the cells were incubated with sodium nitroprusside, the drug inhibited the angiotensin II- or K+-stimulated aldosterone production, and also generated cyclic GMP in the cells. In contrast, dibutyryl cyclic GMP was found to be a stimulator of the aldosterone response rather than an inhibitor. The results obtained in this study cast doubt on the role of cyclic GMP as an intracellular second messenger for the action of ANP on aldosterone secretion.
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Mitsuhiro Okamoto (1988) studied this question.
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