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Three methods have been used to test the carcinogenic response of the lung and pleura of the rat to asbestos. No carcinogenic response of pulmonary epithelium or pleura was noted to either healing infarcts or implanted war pellets that contained asbestos. Sarcomas of the pleura and pericardium developed in 74% of rats in which the pleura was covered with an asbestos-impregnated fibrous glass coat. The fibrous glass alone caused only slight reaction, with complete healing. The last method may serve as an accurate and convenient means of quantitating the neoplastic response of the pleura to asbestos.
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Stanton et al. (1969) studied this question.
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