What question did this study set out to answer?

To review conventional and automated diagnostic tools for monitoring perioperative platelet function in individuals receiving antiplatelet medications.

September 1, 2010Expert Review of Medical Devices

Perioperative assessment of platelet function in patients under antiplatelet therapy

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Population

Patients receiving antiplatelet medication in the perioperative setting

Design

Review

Authors

CHChristoph K. HoferSchulthess-Klinik AZAndreas ZollingerZurich University of Applied Sciences in Business Administration MGMichael T. GanterPrevention Institute

Discussion

Member takes

Implication

Limitations of current tests warrant caution in perioperative antiplatelet decisions; leaves open validation of automated methods in trials.

Key Points

To review conventional and automated diagnostic tools for monitoring perioperative platelet function in individuals receiving antiplatelet medications.
Narrative review of platelet function testing methodologies applied in surgical and perioperative environments.
Evaluation of conventional laboratory tests alongside newer point-of-care, automated, and viscoelastic technologies.
Conventional assays like light-transmission aggregometry and flow cytometry serve as clinical standards but remain labor-intensive, costly, and dependent on specialized expertise.
Automated bedside modalities, such as whole blood aggregometry and viscoelastic techniques, offer rapid evaluation of residual platelet reactivity to optimize individual bleeding and thrombotic risks.

Structured PICO

Population

Patients receiving antiplatelet medication (such as cyclooxygenase-1 inhibitors, adenosine diphosphate antagonists, and glycoprotein IIb/IIIa inhibitors) in the perioperative setting

Intervention

Platelet function testing methods (including light-transmission aggregometry, flow cytometry, whole blood aggregometry, high shear-induced platelet function assessment, and viscoelastic measurement techniques)

This review summarizes available platelet function testing methods and their limitations to guide perioperative management of patients on antiplatelet therapy.

Cite This Study

Hofer et al. (2010) studied this question.

synapsesocial.com/papers/6a8353ec2d06cac57e606966 https://doi.org/10.1586/erd.10.29

Topics

Dual antiplatelet therapy

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Implication

Limitations of current tests warrant caution in perioperative antiplatelet decisions; leaves open validation of automated methods in trials.

Perioperative assessment of platelet function in patients under antiplatelet therapy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Perioperative assessment of platelet function in patients under antiplatelet therapy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider