Young adult (BALB/c x A/J)F(1) hybrid mice have no detectable leukemia viruses. When inoculated with parental BALB/c spleen lymphoid cells, also free of detectable virus, leukemia viruses rapidly become activated in the injected host. Because of similarities between such graft-induced allogeneic disease and spontaneous autoimmunity, it is proposed that autoimmune reactions may activate latent viruses.
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Hirsch et al. (1970) studied this question.
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