January 1, 1991Genes & DevelopmentOpen Access

Troponin I is encoded in the haplolethal region of the Shaker gene complex of Drosophila.

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Population

Drosophila with mutations in the haplolethal region of the Shaker gene complex, specifically complementation…

Design

Preclinical

Authors

JBJulio A. BarbasInstituto Cajal JGJoan GalceránInstituto de Neurociencias IKI. Krah-JentgensInstituto Cajal

Discussion

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Implication

Identifies troponin I's essential developmental roles in Drosophila; leaves open relevance to human muscle or cardiac disease.

Structured PICO

Population

Drosophila (fruit flies) with mutations in the haplolethal (HL) region of the Shaker gene complex (ShC), specifically complementation group HL I

Intervention

Genetic mutations in the HL I complementation group

Outcome

Phenotypic effects of mutations and identification of the encoded proteinsurrogate

The study identifies that the haplolethal region of the Drosophila Shaker gene complex encodes Troponin I, which is essential for muscle and nervous system development and function.

Cite This Study

Barbas et al. (1991) studied this question.

synapsesocial.com/papers/6a835856e8367255819bb438 https://doi.org/10.1101/gad.5.1.132

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Troponin I is encoded in the haplolethal region of the Shaker gene complex of Drosophila.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Troponin I is encoded in the haplolethal region of the Shaker gene complex of Drosophila.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider