This review provides insights into how myosin motor proteins transduce chemical energy into mechanical work by analyzing the structural and functional effects of mutations.
Answers are grounded in this paper and cite their sources.
Structural mapping of myosin mutations advances motor mechanics; leaves open clinical translation to cardiomyopathy management.
Motor proteins perform a wide variety of functions in all eukaryotic cells. Recent advances in the structural and mutagenic analysis of the myosin motor has led to insights into how these motors transduce chemical energy into mechanical work. This review focuses on the analysis of the effects of myosin mutations from a variety of organisms on the in vivo and in vitro properties of this ubiquitous motor and illustrates the positions of these mutations on the high-resolution three-dimensional structure of the myosin motor domain.
No takes yet. Share an insight, caveat, or question.
Ruppel et al. (1996) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: