This review summarizes mutational data on motor proteins to provide insights into their cellular roles and mechanisms of function.
Refines motor protein mechanisms via mutational data; leaves open clinical translation in cardiology.
Mutations in motor proteins, which can arise by design or randomly, provide powerful insights into the normal function of the protein. This review organizes the available data on mutations of members of the myosin, kinesin, and dynein superfamilies of motor proteins. These data contribute to an understanding of the cellular role of the motor proteins as well as provide insights into the fundamental mechanisms of motor function.
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Sweeney et al. (1996) studied this question.
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