What question did this study set out to answer?

To evaluate the relationship between predialysis plasma bicarbonate concentrations and nutritional markers in patients receiving maintenance hemodialysis.

July 1, 2000Seminars in Dialysis

ACID‐BASE IN RENAL FAILURE: Acidosis and Nutritional Status in Hemodialyzed Patients

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To evaluate the relationship between predialysis plasma bicarbonate concentrations and nutritional markers in patients receiving maintenance hemodialysis.
Analyzed cross-sectional registry data from 7,123 hemodialysis patients across France (over 30% of the national dialysis population).
Assessed midweek predialysis bicarbonate, albumin, prealbumin, and BMI, while deriving normalized protein catabolic rate (nPCR) and lean body mass (LBM) using Garred formulas.
Predialysis bicarbonate (mean 22.8 +/- 3.5 mmol/L) demonstrated a highly significant negative correlation with nPCR across the 16 to 30 mmol/L range (p < 0.0001).
Bicarbonate levels showed significant inverse correlations with serum albumin, prealbumin, BMI, and LBM, but had no relationship with dialysis adequacy (Kt/V).

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Implication

Cross-sectional study finds inverse correlations between predialysis bicarbonate and nutritional markers in hemodialysis patients, suggesting dietary protein drives both acidosis and nutrition.

Cite This Study

Chauveau et al. (2000) studied this question.

synapsesocial.com/papers/6a8358c7ec6f123fd66071e9 https://doi.org/10.1046/j.1525-139x.2000.00066.x

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Implication

Cross-sectional study finds inverse correlations between predialysis bicarbonate and nutritional markers in hemodialysis patients, suggesting dietary protein drives both acidosis and nutrition.

ACID‐BASE IN RENAL FAILURE: Acidosis and Nutritional Status in Hemodialyzed Patients

Key Points

Discussion

Implication

Cite This Study

ACID‐BASE IN RENAL FAILURE: Acidosis and Nutritional Status in Hemodialyzed Patients

Key Points

Discussion

Implication

Cite This Study

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