Why the study?
The safety of discontinuing oral anticoagulants after ablation for atrial fibrillation in Japanese patients had not been clarified.
Does discontinuation of oral anticoagulant therapy after atrial fibrillation ablation increase the risk of stroke/TIA or major bleeding?
Does discontinuation of oral anticoagulant therapy after atrial fibrillation ablation increase the risk of stroke/TIA or major bleeding?
Discontinuation of oral anticoagulation after AF ablation appears safe in patients with low baseline stroke risk, as post-ablation stroke/TIA events are driven by baseline CHA2DS2-VASc score rather than OAC discontinuation status.
Supports OAC discontinuation in low CHA2DS2-VASc patients post-AF ablation; leaves open need for randomized confirmation.
BACKGROUND: The safety of discontinuing oral anticoagulant (OAC) after ablation for atrial fibrillation (AF) in Japanese patients has not been clarified. METHODS AND RESULTS: -VASc scores but not with OAC status. CONCLUSIONS: Although the incidences of stroke/TIA, major bleeding, and death were relatively low among patients for whom OAC therapy was discontinued, stroke/TIA occurrence was strongly associated with a high baseline stroke risk rather than with OAC status. Thus, discontinuation of OAC therapy requires careful consideration, especially in patients with a high baseline stroke risk.
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Okumura et al. (2019) studied this question.
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