Acetaldehyde is an intermediate in alcoholic fermentation. The major part of it is reduced to ethanol but a minor fraction is normally oxidized to acetic acid. Owing to the kinetic properties of alcohol dehydrogenase and aldehyde dehydrogenase, the oxidized fraction decreased as the intracellular concentration was increased. Since alcohol dehydrogenase catalyses a reversible reaction, the distribution between oxidation and reduction of acetaldehyde was sensitive to the concentration of ethanol; an increased concentration of ethanol reduced the formation of acetic acid.
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Kurt Nordström (1968) studied this question.
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