Population
single KcsA channels
Design
Preclinical
Authors
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Punchthrough mechanism refines K+ channel biophysics models; clinical relevance to human cardiac channels remains untested.
The study elucidates the mechanism of voltage-dependent Na+ block and permeation in KcsA channels, highlighting a 'punchthrough' mechanism at high voltages.
Nimigean et al. (2002) studied this question.
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