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Laboratory study reveals inverse regulation of hepatic cholesterol synthesis by dietary intake in animals, indicating an intrinsic feedback mechanism for plasma homeostasis.
Despite wide variations in dietary cholesterol, most animals are capable of maintaining the cho- lesterol of their plasma at relatively constant levels. Insight into the means by which this homeo- statis of plasma cholesterol is accomplished was first provided when Gould and associates (3-5), Tom- kins, Sheppard and Chaikoff (6) and Frantz, Schneider and Hinkelman (7) independently dem- onstrated that cholesterol synthesis in the liver varies inversely with the level of dietary choles- terol. Since all endogenous plasma cholesterol probably originates in the liver (8-10), it is likely that the constancy of plasma cholesterol is the result of this reciprocal relationship between dietary cholesterol and hepatic cholesterogenesis.
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Siperstein et al. (1960) studied this question.
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