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Colloidal gold particles are used as hard, spherical imaging targets to assist in the three-dimensional reconstruction of the atomic force probe apex. Probe reconstructions are shown to be accurate to 1 nm resolution and dynamically change as the sample is scanned, emphasizing the utility of colloidal gold particles as in situ calibration standards for image reconstruction of a coadsorbed specimen.
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Vesenka et al. (1994) studied this question.
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