Why the study?
Lower adiponectin concentrations have been linked to coronary heart disease risk, but whether similar relationships exist for peripheral vascular disease was uncertain.
Is decreased total adiponectin associated with an increased risk of symptomatic lower extremity peripheral vascular disease in patients with type 2 diabetes mellitus?
Is decreased total adiponectin associated with an increased risk of symptomatic lower extremity peripheral vascular disease in patients with type 2 diabetes mellitus?
Decreased total adiponectin levels are significantly associated with an increased risk of symptomatic lower extremity peripheral vascular disease in patients with type 2 diabetes.
Supports adiponectin as potential PVD biomarker in diabetes; hypothesis-generating and should not yet change practice.
Objective: Adiponectin is an adipocyte-derived protein that has gained considerable research interest because of its pleiotropic effects on insulin sensitivity, atherosclerosis and inflammation. Lower concentrations of adiponectin have been linked to subsequent risk of coronary heart disease in healthy individuals. Whether similar relationships exist for the development of systemic atherosclerosis, such as peripheral vascular disease (PVD), is uncertain. We investigated the association between total adiponectin and risk of lower extremity PVD.
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Shajithanoop Selva kumar (2019) studied this question.
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