Why the study?
What are the unfavorable reactions associated with the formaldehyde-inactivated poliomyelitis vaccine?
What are the unfavorable reactions associated with the formaldehyde-inactivated poliomyelitis vaccine?
The formaldehyde-inactivated poliomyelitis vaccine demonstrates a very high safety profile with an extremely low rate of reported adverse reactions.
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Affirms inactivated polio vaccine safety for routine use; leaves open need for active surveillance of rare events.
Complaints received by a manufacturer from physicians concerning unfavorable reactions to formaldehyde-inactivated poliomyelitis vaccine have been analyzed. The use of 184,000,000 doses of vaccine was followed by 284 complaints, of which 138 concerned only stinging or burning local pain. In six instances the symptoms suggested poliomyelitis, but in no case were the three essential criteria of inoculation-induced poliomyelitis satisfied. The most severe reactions reported in connection with this vaccine were four anaphylactoid reactions, and in each case recovery was complete. The most frequent types of reaction were allergic (56 cases) and neurological (37). The complaint rate was therefore extremely low, and the relative safety of the vaccine was apparent.
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Charles N. Christensen (1959) studied this question.
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