Why the study?
Does intramuscular poliomyelitis vaccination increase neutralizing antibodies in infants and preschool children?
Population
251 infants and preschool children, ages ranging from 2 months to 5 years
Comparison
Intramuscular inoculation of poliomyelitis vaccine vs Different vaccination schedules
Design
Cohort
Follow-up
6 months
Authors
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Multiple-dose schedules may be needed for adequate antibody responses in children; leaves open optimal modern regimens and clinical protection.
Does intramuscular poliomyelitis vaccination increase neutralizing antibodies in infants and preschool children?
Multiple injections of the poliomyelitis vaccine are required to elicit a robust neutralizing antibody response in infants and preschool children.
Gordon C. Brown (1956) studied this question.
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