Key result
Multi-dose Sabin vaccine yields the highest antibody levels without interference from maternal passive antibodies.
Why the study?
Does attenuated poliovirus vaccine (Sabin) administered via different schedules improve immunologic response in young infants?
Does attenuated poliovirus vaccine (Sabin) administered via different schedules improve immunologic response in young infants?
Multiple doses of attenuated poliovirus vaccine, either monovalent or trivalent, elicit the highest antibody responses in infants, regardless of maternal passive antibodies.
Multiple-dose Sabin schedules may enhance infant antibody responses without maternal interference; hypothesis-generating for contemporary polio immunization strategies.
Attenuated poliovirus vaccine (Sabin) was given to 90 young infants by 5 schedules of administration in order to determine the degrees of immunologic response and the influence of placentally transferred passive antibodies. Group 1 received 3 vaccine types at 6-week intervals as monovalent vaccine; Group 2 received 3 types administered together on 3 separate occasions; Groups 3, 4, and 5 received the 3 types as a single dose at 6 weeks, 12 weeks, and 18 weeks of age, respectively. A sixth group, as a contratest, did not receive vaccine. Groups 1 and 2 developed the highest antibody levels. High levels of passive antibody of maternal origin did not interfere with production of active antibody.
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Randolph Batson (1962) studied Poliomyelitis immunization (n=90). Attenuated poliovirus vaccine (Sabin) vs. No vaccine was evaluated on Immunologic response and influence of placentally transferred passive antibodies. Attenuated poliovirus vaccine (Sabin) produced the highest antibody levels when given in multiple doses, and maternal passive antibodies did not interfere with active antibody production.
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