December 15, 1956JAMA

Antigenic Potency of Poliomyelitis Vaccine

View Full Paper

Ask AI

Bookmark

Why the study?

Does the poliomyelitis vaccine produce sustained and increased antibody titers after primary and booster inoculations in children?

Population

Children receiving poliomyelitis vaccine

Comparison

Poliomyelitis vaccine vs Pre-inoculation baseline, or comparison between…

Design

Cohort

Follow-up

1 year

Authors

JSJonas SalkBlaze Bioscience (United States)

Discussion

Member takes

Implication

Supports three-dose polio vaccination for robust antibody responses in children; extends immunogenicity data but leaves open randomized confirmation of clinical protection.

Structured PICO

Does the poliomyelitis vaccine produce sustained and increased antibody titers after primary and booster inoculations in children?

Population

Children receiving poliomyelitis vaccine (n=4,617 in the main cohort, with smaller cohorts of 186, 115, and 214 subjects)

Intervention

Poliomyelitis vaccine (multiple doses including primary and booster injections)

Comparator

Pre-inoculation baseline, or comparison between commercial and laboratory-prepared lots

Outcome

Antibody titer levels (persistence over a year and increase in response to booster/second doses)surrogate

Three doses of the poliomyelitis vaccine effectively produce high and sustained antibody titers comparable to naturally acquired infection-immunity.

Cite This Study

Jonas Salk (1956) studied this question.

synapsesocial.com/papers/6a8bfa5252e1a91077e988be https://doi.org/10.1001/jama.1956.02970330023006

View Full Paper

Ask AI

Bookmark

December 15, 1956JAMA

Antigenic Potency of Poliomyelitis Vaccine

View Full Paper

Ask AI

Bookmark

Why the study?

Does the poliomyelitis vaccine produce sustained and increased antibody titers after primary and booster inoculations in children?

Population

Children receiving poliomyelitis vaccine

Comparison

Poliomyelitis vaccine vs Pre-inoculation baseline, or comparison between…

Design

Cohort

Follow-up

1 year

Authors

JSJonas SalkBlaze Bioscience (United States)

Discussion

Member takes

Implication

Supports three-dose polio vaccination for robust antibody responses in children; extends immunogenicity data but leaves open randomized confirmation of clinical protection.

Structured PICO

Does the poliomyelitis vaccine produce sustained and increased antibody titers after primary and booster inoculations in children?

Population

Children receiving poliomyelitis vaccine (n=4,617 in the main cohort, with smaller cohorts of 186, 115, and 214 subjects)

Intervention

Poliomyelitis vaccine (multiple doses including primary and booster injections)

Comparator

Pre-inoculation baseline, or comparison between commercial and laboratory-prepared lots

Outcome

Antibody titer levels (persistence over a year and increase in response to booster/second doses)surrogate

Three doses of the poliomyelitis vaccine effectively produce high and sustained antibody titers comparable to naturally acquired infection-immunity.

Cite This Study

Jonas Salk (1956) studied this question.

synapsesocial.com/papers/6a8bfa5252e1a91077e988be https://doi.org/10.1001/jama.1956.02970330023006

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark