Key result
All tested poliomyelitis vaccines produced good antibody responses to Types 2 and 3, but commercial vaccines were less satisfactory for Type 1 compared to an experimental vaccine fortified with extra Type 1 component.
Why the study?
How do different commercial and experimental poliomyelitis vaccines compare in their ability to induce antibody responses to poliovirus Types 1, 2, and 3?
Observational (n=226)
How do different commercial and experimental poliomyelitis vaccines compare in their ability to induce antibody responses to poliovirus Types 1, 2, and 3?
Commercial poliomyelitis vaccines used in the UK in 1958 produced adequate responses to Types 2 and 3 but required fortification with extra Type 1 antigen to achieve satisfactory Type 1 immunity.
Commercial vaccines may require Type 1 fortification for optimal responses; leaves open relevance to modern schedules.
The potency in man of eight different commercial vaccines and an experimental vaccine, as judged by the antibody response after the primary course of two injections and after a booster dose 9–12 months later, was compared. All the vaccines produced good responses to Types 2 and 3 but some were less satisfactory for Type 1. The relation of potency to protection in man is discussed and the use of one of the vaccines as a minimum standard for this country is suggested.
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Kendall et al. (1960) conducted an observational in Poliomyelitis vaccination (n=226). Poliomyelitis vaccines (commercial A-H and experimental S 2) vs. Different vaccine batches compared to each other was evaluated on Antibody response (titres > 100) to poliovirus Types 1, 2, and 3 after a booster dose. All tested poliomyelitis vaccines produced good antibody responses to Types 2 and 3, but commercial vaccines were less satisfactory for Type 1 compared to an experimental vaccine fortified with extra Type 1 component.
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