The study demonstrates high overall immunity to poliovirus but highlights a concerning drop in type 3 antibodies among older children, emphasizing the need for school-leaving booster doses.
High seroprevalence suggests adequate population immunity; leaves open whether type 3 protection wanes in adolescents.
Serum from 995 subjects aged 6 months to 99 years was screened at a dilution of 1/8 for neutralising antibodies to poliovirus. Of these samples, 975 (98%) contained antibody to at least one serotype, and 763 (77%) contained antibody to all three, an improvement since previous studies. Children aged 8 to 15, however, had a low prevalence of antibody to poliovirus type 3, with only four (40%) of those aged 12 protected. This finding is possibly due to the waning of antibodies induced by the type 3 component of oral poliovirus vaccine and emphasises the continued importance of a booster dose of vaccine for those leaving school.
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White et al. (1986) studied this question.
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