Why the study?
Does primary immunization with poliomyelitis vaccine maintain high antibody levels at 12 months in young infants?
Does primary immunization with poliomyelitis vaccine maintain high antibody levels at 12 months in young infants?
Poliomyelitis antibody levels decrease significantly 12 months after the third vaccine dose in young infants, suggesting the need for a fourth booster dose.
Antibody decline by 12 months after third polio dose in infants warrants schedule caution; leaves open need for boosters pending randomized protection data.
Data has been presented showing that, although 4 months after the third injection of poliomyelitis vaccine, antibody levels were quite high, at 12 months there was a definite and striking decrease in antibody titers. It is suggested that serious consideration be given to the routine administration of a fourth, 1-ml, injection of poliomyelitis vaccine 12 months after the third injection. It would seem advisable to follow this practice unless it can be demonstrated that the state and degree of hypersensitivity, without detectable antibodies, is sufficiently great to result in a protective response when natural infection occurs.
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Batson et al. (1959) studied this question.
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