What question did this study set out to answer?

To introduce a spirally cut isolated tracheal strip preparation for investigating airway smooth muscle pharmacology.

June 1, 1965Journal of Pharmacy and Pharmacology

The spirally cut tracheal strip preparation

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Authors

JCJay W. ConstantinePfizer (United States)

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Implication

Methodological report demonstrates isolated spirally cut tracheal tissue preparation, highlighting improved precision for evaluating airway smooth muscle responses to drugs.

Key Points

To introduce a spirally cut isolated tracheal strip preparation for investigating airway smooth muscle pharmacology.
Isolated mammalian tracheal tissue and sectioned it spirally into a continuous strip.
Mounted the spiral strip in an isolated organ bath system to record mechanical contractile and relaxant responses to pharmacological stimuli.
Demonstrated that spiral cutting aligns smooth muscle fibers to generate measurable, uniform mechanical responses during in vitro assays.
Provided an established experimental technique to evaluate bronchodilator and bronchoconstrictor compounds on intact airway muscle.

Cite This Study

Jay W. Constantine (1965) studied this question.

synapsesocial.com/papers/6a836e379492d09e1bb3fe58 https://doi.org/10.1111/j.2042-7158.1965.tb07688.x

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Implication

Methodological report demonstrates isolated spirally cut tracheal tissue preparation, highlighting improved precision for evaluating airway smooth muscle responses to drugs.

The spirally cut tracheal strip preparation

Discussion

Member takes

Implication

Key Points

Cite This Study

The spirally cut tracheal strip preparation

Discussion

Member takes

Implication

Key Points

Cite This Study

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