Population
Excised cross-circulated dog left ventricles
Comparison
15-minute normothermic global ischemia followed… vs Preischemic control state
Design
Preclinical
Follow-up
60-120 minutes of reperfusion
Authors
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Suggests inefficiency in stunned myocardium energetics; hypothesis-generating and requires human validation before clinical consideration.
In a canine model of stunned myocardium, unchanged oxygen consumption despite depressed contractility is primarily driven by an increased oxygen cost of contractility.
Ohgoshi et al. (1991) studied this question.
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