Why the study?
Does intravenous angiotensin II alter blood flow to choroid plexuses in anesthetized rats?
Population
Pentobarbital-anesthetized rats
Comparison
Angiotensin II infused intravenously at rates of… vs Baseline or different doses of Angiotensin II
Design
Preclinical
Authors
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May reduce choroid plexus perfusion in rats via AT1/AT2; leaves open relevance to human CSF regulation.
Does intravenous angiotensin II alter blood flow to choroid plexuses in anesthetized rats?
Moderate doses of intravenous angiotensin II decrease blood flow to specific choroid plexuses in rats, an effect mediated by both AT1 and AT2 receptors.
Chodobski et al. (1995) studied this question.
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