The question was asked whether the proximo‐distal regional organization of regenerating urodele limbs is the result of an epidermal‐mesodermal interaction, as is the case in the embryonic limb bud. Epidermal deletion experiments on regeneration blastemas of various stages have answered this question in the affirmative. The mechanisms involved in the morphogenesis of the regeneration blastema are therefore very similar to those operating in the morphogenesis of embryonic limb buds.
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Stocum et al. (1972) studied this question.