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December 1, 1988Journal of Biological ChemistryOpen Access

The iron-responsive element is the single element responsible for iron-dependent translational regulation of ferritin biosynthesis. Evidence for function as the binding site for a translational repressor.

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Authors

SCS. Wright CaughmanEmory Healthcare
Matthias W. Hentze
Matthias W. HentzeTufts UniversityTRTracey A. RouaultCentre d'Études Scientifiques et Techniques d'Aquitaine

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Cite This Study

Caughman et al. (1988) studied this question.

synapsesocial.com/papers/6a836fdb3965fa42e1c94b81https://doi.org/10.1016/s0021-9258(18)37387-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Iron-Responsive Elements: Regulatory RNA Sequences That Control mRNA Levels and Translation1988 · 724 citations
  2. 2Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs.1988 · 687 citations
  3. 3The importance of the 3'-untranslated region in the translational control of ferritin mRNA.1988 · 84 citations
  4. 4Novel mechanism for translational control in regulation of ferritin synthesis by iron.1976 · 326 citations
  5. 5A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron.1987 · 255 citations