December 8, 2004Thrombosis and HaemostasisOpen Access

Mortality rates and risk factors for asymptomatic deep vein thrombosis in medical patients

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Why the study?

Does asymptomatic proximal DVT increase 90-day mortality in hospitalized medical patients?

Population

1,738 hospitalized patients with acute medical illness who had not sustained a symptomatic venous…

Comparison

Asymptomatic proximal deep vein thrombosis or… vs No DVT (Group III, N=1540)

Design

Cohort

Follow-up

90 days

Authors

ALAlain LeizoroviczVascular Medicine ACAlexander CohenBoston Children's Hospital ATAlexander G.G. TurpieVascular Medicine

Discussion

Member takes

Implication

Asymptomatic proximal DVT was associated with higher 90-day mortality; supports its role as trial endpoint but should not yet change practice.

Structured PICO

Does asymptomatic proximal DVT increase 90-day mortality in hospitalized medical patients?

Population

1,738 hospitalized patients with acute medical illness (age ≥40 years, projected hospitalization ≥4 days, ≤3 days prior immobilization) who had not sustained a symptomatic venous thromboembolic event by Day 21 and had a complete compression ultrasound of the proximal and distal leg veins on Day 21.

Intervention

Asymptomatic proximal deep vein thrombosis (DVT) (Group I, N=80) or asymptomatic distal DVT (Group II, N=118)

Comparator

No DVT (Group III, N=1540)

Outcome

90-day mortalityhard clinical

Asymptomatic proximal DVT in acutely ill hospitalized medical patients is associated with a significantly increased risk of 90-day mortality, supporting its use as a clinical endpoint in thromboprophylaxis trials.

Limitations

Compression ultrasound is less accurate for diagnosing distal DVT
Association between proximal DVT and subsequent mortality does not necessarily establish causality
Precise contribution of VTE to observed fatalities is uncertain without autopsy data
Developing a DVT could be a marker for severe underlying illness

Cite This Study

Leizorovicz et al. (2004) studied this question.

synapsesocial.com/papers/6a837241e16cf3053ea6488c https://doi.org/10.1160/th04-05-0323

Topics

Women and heart disease

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Implication

Asymptomatic proximal DVT was associated with higher 90-day mortality; supports its role as trial endpoint but should not yet change practice.

Mortality rates and risk factors for asymptomatic deep vein thrombosis in medical patients

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Mortality rates and risk factors for asymptomatic deep vein thrombosis in medical patients

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider