Why the study?
Optimal perioperative fluid management remains uncertain, and whether restrictive fluid therapy is more beneficial and cost-effective than goal-directed fluid therapy was unknown.
Does restrictive fluid therapy reduce major complications or mortality compared to goal-directed fluid therapy in adults undergoing major non-cardiac surgery?
Population
562 adults undergoing major elective non-cardiac surgery across 6 RCTs
Comparison
Perioperative restrictive fluid therapy vs goal-directed fluid therapy
Design
Systematic review and meta-analysis of RCTs
Authors
Loading...
Very low-certainty evidence leaves optimal fluid strategy unresolved; does not support shifting from goal-directed to restrictive therapy in major non-cardiac surgery.
Does restrictive fluid therapy reduce major complications or mortality compared to goal-directed fluid therapy in adults undergoing major non-cardiac surgery?
In adults undergoing major non-cardiac surgery, very low-certainty evidence suggests restrictive fluid therapy does not reduce major complications and may potentially increase mortality compared to goal-directed fluid therapy.
Wrzosek et al. (2019) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: