Why the study?
Does OPV exposure lead to prolonged poliovirus shedding in children with antibody deficiency disorders?
Population
15 children diagnosed with primary antibody deficiency and/or specific syndromes with defects in antibody…
Design
Cohort
Follow-up
6 months
Authors
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Low prolonged shedding observed in small cohort; leaves open whether OPV is safe in antibody-deficient children, needing larger studies.
Does OPV exposure lead to prolonged poliovirus shedding in children with antibody deficiency disorders?
The study demonstrates a low occurrence of prolonged vaccine poliovirus shedding in children with primary antibody deficiency disorders exposed to live oral poliovirus vaccine.
Galal et al. (2012) studied this question.
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