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The appearance and clinical significance of round cells and acid mucosubstances in the tumour stroma were investigated in 80 patients with epidermoid carcinoma of the tongue. It was found that on the average the prognosis was better in the cases where the round cell reaction in the tumour stroma was positive, and also in the cases where the acid mucosubstance reaction was negative in the tumour stroma. Furthermore, an inverse correlation between the appearance of round cells and acid mucosubstances was noted.
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Paavolainen et al. (1973) studied this question.
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