Why the study?
Which drugs are potentially associated with an increased risk of acute myocardial infarction in a real-world healthcare data network?
Population
21,171,291 individuals from seven population-based healthcare databases in Denmark, Italy, and the Netherlands
Design
Cohort
Follow-up
1996-2010 (154,474,063 person-years)
Authors
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These associations warrant no prescribing changes yet; hypothesis-generating and require prospective confirmation.
Which drugs are potentially associated with an increased risk of acute myocardial infarction in a real-world healthcare data network?
A large-scale electronic healthcare records surveillance identified nine drugs, including several macrolides and prokinetics, as novel 'prime suspects' for drug-induced acute myocardial infarction.
Coloma et al. (2013) studied this question.
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