Ampicillin in the Treatment of Enterococcal Endocarditis

Article1 October 1966Ampicillin in the Treatment of Enterococcal EndocarditisHARRY N. BEATY, M.D., MARVIN TURCK, M.D., ROBERT G. PETERSDORF, M.D., F.A.C.P.HARRY N. BEATY, M.D.Search for more papers by this author, MARVIN TURCK, M.D.Search for more papers by this author, ROBERT G. PETERSDORF, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-4-701 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe currently recommended treatment for enterococcal endocarditis consists of high doses of aqueous penicillin intravenously, given in combination with intramuscular streptomycin for 6 weeks (1). If antibiotic dosage is regulated to maintain a constant bactericidal activity against the infecting strain in at least a 1:4 dilution of the patient's serum, the bacteriologic cure rate for this infection approaches that achieved for highly penicillin-sensitiveStreptococcus viridansendocarditis (1, 2). Although the penicillin-streptomycin regimen is eminently satisfactory from the therapeutic point of view, it involves considerable inconvenience, cost, and the potential risk of ototoxicity. For these reasons, it seems reasonable to seek...References1. KOENIGKAYE MGD: Enterococcal endocarditis. Report of nineteen cases with long-term follow-up data. New Eng. J. Med. 264: 257, 1961. CrossrefMedlineGoogle Scholar2. GERACI JE: Antibiotic therapy of bacterial endocarditis: therapeutic data on 172 patients seen from 1951 through 1957: additional observations on short term therapy (two weeks) for penicillin-sensitive streptococcal endocarditis. Med. Clin. N. Amer. 42: 1101, 1958. 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Braun-Brumfield, Inc., Ann Arbor, 1963, p. 314. Google Scholar18. STRATFORD BC: Clinical and laboratory experiences with ampicillin ("Penbritin"). Med. J. Aust. 49(2): 414, 1962. CrossrefMedlineGoogle Scholar19. GRAYTAIWALLACECALDER IRARJGJH: Oral treatment of bacterial endocarditis with penicillins. Lancet 2: 110, 1964. CrossrefMedlineGoogle Scholar20. BURNELL RH: The successful treatment of a case of bacterial endocarditis with ampicillin. Med. J. Aust. 2: 60, 1964. CrossrefMedlineGoogle Scholar21. BUNNO'BRIENBENTLEYHAYMAN PJDH: Further experiences with ampicillin, in Antimicrobial Agents and Chemotherapy, edited by SYLVESTER, J. C. Braun-Brumfield, Inc., Ann Arbor, 1962, p. 323. Google Scholar22. LLOYD-STILL JD: Bacterial endocarditis and urology. Brit. Med. J. 1: 768, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HARRY N. BEATY, M.D.; MARVIN TURCK, M.D.; ROBERT G. PETERSDORF, M.D., F.A.C.P.Affiliations: Seattle, WashingtonFrom the Department of Medicine, University of Washington School of Medicine, and King County Hospital, Seattle, Wash.This study was supported in part by a grant from the Boeing Good Neighbor Fund.Requests for reprints should be addressed to Harry N. Beaty, M.D., King County Hospital, 325 9th Ave., Seattle, Wash. 98104. 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Annual review of significant publications 1 October 1966Volume 65, Issue 4Page: 701-707KeywordsEndocarditisEnterococcus infectionsHospital medicinePenicillinStreptococcal infectionsStreptococcusStreptomycin ePublished: 1 December 2008 Issue Published: 1 October 1966 PDF downloadLoading ...