Early bilateral ovariectomy in aged mice on a high-cholesterol diet provides a new model for studying left ventricle hypertrophy in postmenopausal osteoporosis.
Should not yet change clinical practice; extends preclinical models for postmenopausal LVH.
This article uses in vivo and ex vivo analysis to track the development of osteoporosis and left heart cardiovascular disease in an aged, high-cholesterol diet, mouse ovariectomy model. Mice develop early left ventricle hypertrophy without concurrent fibrosis or aortic valve stenosis. These findings allow for a new model of the study of left ventricle hypertrophy in postmenopausal osteoporosis that more closely mimics the natural progression of disease in female patients.
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Joll et al. (2022) studied this question.
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