Why the study?
Does osteoblast ablation affect glucose metabolism and energy expenditure independently of osteocalcin in mice?
Population
Transgenic mice expressing a tamoxifen-regulated Cre under the control of the osteocalcin promoter…
Comparison
Inducible ablation of osteoblasts, followed by… vs Osteocalcin-deficient mice phenotype
Design
Preclinical
Authors
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Osteoblast-derived factors beyond osteocalcin may regulate glucose metabolism in mice; hypothesis-generating for human bone-endocrine links.
Does osteoblast ablation affect glucose metabolism and energy expenditure independently of osteocalcin in mice?
Osteoblasts are necessary for glucose homeostasis and energy expenditure, suggesting that in addition to osteocalcin, other osteoblast-derived hormones regulate energy metabolism.
Yoshikawa et al. (2011) studied this question.
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