Why the study?
Cardiac aging leads to impaired heart function and heart failure, creating an urgent need for efficient strategies to address age-related cardiac dysfunction linked to metabolic imbalance.
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Design
Review
Extends metabolic insights in cardiac aging; leaves open whether targeted therapies will improve clinical outcomes.
Cardiac aging is accompanied by progressive loss of cellular function, leading to impaired heart function and heart failure. There is an urgent need for efficient strategies to combat this age-related cardiac dysfunction. A growing number of events suggest that age-related cardiac diseases are tightly related to metabolic imbalance. This review summarizes recent findings concerning metabolic changes during cardiac aging and highlights the therapeutic approaches that target metabolic pathways in cardiac aging.
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Liu et al. (2022) studied this question.
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