In Kawasaki disease, MMP-9 is predominantly found in granulocytes and TIMP-1 in platelets, suggesting that targeting granulocyte activity may help prevent coronary aneurysms.
Answers are grounded in this paper and cite their sources.
May implicate granulocyte MMP-9 in Kawasaki disease coronary complications; hypothesis-generating and requires prospective validation before any targeting.
The interaction of matrix metalloproteinase (MMP)-9 and tissue inhibitor of matrix metalloproteinase-1 has been implicated in the formation of coronary aneurysms in Kawasaki disease. MMP-9 and tissue inhibitor of matrix metalloproteinase-1 were distributed predominantly in the granulocytes and platelets, respectively, in patients with Kawasaki disease. The plasma values of MMP-9 correlated positively with the circulating neutrophil count. Inhibiting the activity of granulocytes and maintaining the platelet activity might prevent coronary aneurysms.
No takes yet. Share an insight, caveat, or question.
Korematsu et al. (2012) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: