Six obese patients were treated with triiodothyronine (T3) for periods ranging from 30 to 120 days. The excretion of nitrogen increased significantly in all, but potassium excretion was elevated in only 2. All patients showed a rise in oxygen consumption. Growth hormone, given along with T3 to 4 patients, caused retention of nitrogen and potassium, and was associated with a further rise in oxygen consumption in 3 subjects. The excretion of nitrogen and potassium was significantly reduced by different anabolic steroids given to 4 patients during treatment with triiodothyronine. Human placental lactogen was without effect on nitrogen excretion or on the consumption of oxygen.
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Bray et al. (1971) studied this question.