Role of BAG3 in cancer progression: A therapeutic opportunity

Margot De Marco; Anna Basile; Vittoria Iorio; Michelina Festa; Antonia Falco; Maria Pascale; Gianluca Sala; Paolo Remondelli; Mario Capunzo; Matthew A. Firpo; Raffaele Pezzilli; Liberato Marzullo; Pierpaolo Cavallo; Vincenzo De Laurenzi; Maria Caterina Turco; Alessandra Rosati

doi:10.1016/j.semcdb.2017.08.049

August 31, 2017Seminars in Cell and Developmental BiologyOpen Access

Role of BAG3 in cancer progression: A therapeutic opportunity

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Key Points

To delineate the molecular mechanisms of intracellular and secreted BAG3 in driving cancer progression and evaluate its promise as an anti-tumor therapeutic target.
Examined the structural motifs of BAG3 (BAG domain, WW domain, PXXP repeat, and IPV motifs) and its binding partners, including heat shock protein 70.
Assessed pathways influenced by intracellular BAG3 expression across tissues and stress states, alongside secreted BAG3 interactions within the tumor microenvironment.
Intracellular BAG3 modulates critical cellular pathways—including apoptosis, autophagy, mechanotransduction, and motility—by altering partner protein levels, localization, and activity.
Pancreatic ductal adenocarcinoma cells release a secreted form of BAG3 that binds macrophage IFITM2 receptors, triggering the release of factors supporting tumor growth and metastasis.
Neutralizing extracellular BAG3 represents an actionable intervention to block pro-tumorigenic macrophage signaling and inhibit cancer dissemination.

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Implication

Molecular review demonstrates BAG3-driven tumor progression and microenvironment signaling in pancreatic cancer, suggesting targeted neutralization as a viable therapeutic strategy.

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Marco et al. (2017) studied this question.

synapsesocial.com/papers/6a8384983b7a764e132a4db2 https://doi.org/10.1016/j.semcdb.2017.08.049

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Role of BAG3 in cancer progression: A therapeutic opportunity

Key Points

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Discussion

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Role of BAG3 in cancer progression: A therapeutic opportunity

Key Points

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Implication

Discussion

Cite This Study

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