Detection of soluble BAG3 and anti-BAG3 antibodies in patients with chronic heart failure

Margot De Marco; Antonia Falco; Anna Basile; Alessandra Rosati; Michela Festa; Morena d’Avenia; Maria Pascale; Fabrizio Dal Piaz; Rita Bisogni; Daniela Barcaroli; Giangennaro Coppola; Federico Piscione; Alberto Gigantino; Rodolfo Citro; Roberta De Rosa; Gennaro Vitulano; Nicola Virtuoso; Fiore Manganelli; Ester Palermo; Francesco Siano; Giuseppe Rosato; Michael Hahne; Claudio Tiberti; Vincenzo De Laurenzi; Maria Caterina Turco

doi:10.1038/cddis.2013.8

Structured PICO

P

Population

52 patients with chronic heart failure (EF < 45%), mean age 58.5, 43 male, and 84 healthy donors, mean age 49.6, 65 male. Also includes in vitro models (rat H9c2 and human HCMa cardiomyocytes).

C

Comparator

Healthy subjects

O

Outcome

Detection of soluble BAG3 and anti-BAG3 antibodies in serasurrogate

Soluble BAG3 and anti-BAG3 antibodies are detectable in the sera of patients with chronic heart failure, suggesting a potential role as a biomarker.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

May support anti-BAG3 antibodies as a heart failure biomarker; hypothesis-generating from case-control data and requires prospective validation.

Abstract

No abstract yet. The journal hasn't published one we can show.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Marco et al. (2013) studied this question.

synapsesocial.com/papers/6a9063046419f6799027a7d2 https://doi.org/10.1038/cddis.2013.8

View Full Paper

Ask AI

Bookmark

Share

Detection of soluble BAG3 and anti-BAG3 antibodies in patients with chronic heart failure

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Detection of soluble BAG3 and anti-BAG3 antibodies in patients with chronic heart failure

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading