Why the study?
Does pindolol improve myocardial blood flow, metabolism and function in patients with coronary heart disease?
Does pindolol improve myocardial blood flow, metabolism and function in patients with coronary heart disease?
Pindolol relieves angina pectoris symptoms through mechanisms independent of changes in overall myocardial blood flow or hemodynamics, possibly via metabolic effects or blood flow redistribution.
Answers are grounded in this paper and cite their sources.
May support metabolic effects of pindolol in angina independent of hemodynamics; leaves open confirmation in randomized trials.
1 The study was designed to elucidate further the mechanism by which beta-adrenoceptor antagonism with pindolol relieves the symptoms of angina pectoris in patients with coronary heart disease. 2 Pindolol administration was associated with an elevated threshold for angina pectoris and improved myocardial lactate metabolism during supraventricular pacing. 3 This beneficial effect of pindolol was independent of changes in myocardial blood flow and was not mediated by haemodynamic effects. 4 The results suggest that in angina pectoris, in addition to the recognized beneficial effects of beta-adrenoceptor blockade, the actions of pindolol also result from, as yet, poorly described phenomena such as redistribution of myocardial blood flow or metabolic effects.
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Küpper et al. (1982) studied this question.
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