Why the study?
Do atenolol and pindolol affect phorbol ester-induced coronary vasoconstriction in isolated perfused rat hearts?
Population
Isolated perfused heart of the rat
Comparison
Atenolol and pindolol vs Phorbol ester (TPA) alone, or each other
Design
Preclinical
Authors
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Hypothesis-generating for partial agonist beta-blockers in coronary tone; leaves open human translation.
Do atenolol and pindolol affect phorbol ester-induced coronary vasoconstriction in isolated perfused rat hearts?
In isolated rat hearts, pindolol but not atenolol attenuates phorbol ester-induced coronary vasoconstriction, suggesting that beta-blockers with partial agonistic activity may help maintain coronary flow.
Heikki Ruskoaho (1988) studied this question.
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