Bepridil intoxication can cause lethal torsade de pointes during pacemaker generator exchange, highlighting the need for careful medication review in pacemaker clinics.
Bepridil toxicity may trigger torsade during device exchange; this case leaves open whether pre-procedure screening alters risk.
A 92-year-old small-framed man developed torsade de pointes during pacemaker-generator exchange. His family physician prescribed bepridil 200 mg/day. High bepridil concentration of 1409 ng/mL was revealed. Electrophysiologists at pacemaker clinic should pay attention to arrhythmia management including bepridil concentration when the family physician prescribes bepridil to a pacemaker patient.
No takes yet. Share an insight, caveat, or question.
Ajiro et al. (2020) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: