Population
Isolated pulmonary vein and left atrium preparations from male or female Hartley guinea pigs weighing…
Comparison
Bepridil 1 µM and 10 µM added to organ bath. vs Pre-drug baseline and left atrium preparation.
Design
Preclinical
Authors
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May support bepridil's AF efficacy via pulmonary vein selectivity; hypothesis-generating in animal models, requiring human validation.
Bepridil exerts greater electrophysiological effects on the pulmonary vein than the left atrium, providing mechanistic insight into its efficacy for atrial fibrillation.
Takahara et al. (2013) studied this question.
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