What question did this study set out to answer?

To evaluate the therapeutic efficacy of transcutaneous auricular vagus nerve stimulation on cognitive performance, anxiety-like behaviors, and hippocampal glial and neurotrophic markers in morphine-withdrawn rats.

April 1, 2025Addiction BiologyOpen Access

Transcutaneous Auricular Vagus Nerve Stimulation Restores Cognitive Impairment in Morphine‐Withdrawn Rats: Role of BDNF and Glial Cells in the Hippocampus

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Authors

SNSomayeh NazariShiraz University of Medical Sciences SNSaba NiknamfarMazandaran University of Medical Sciences HGHamed GhazviniMazandaran University of Medical Sciences

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Implication

Animal study demonstrates that auricular vagus nerve stimulation restores memory in morphine-withdrawn rats, suggesting a noninvasive adjunct therapy for opioid use disorder.

Key Points

To evaluate the therapeutic efficacy of transcutaneous auricular vagus nerve stimulation on cognitive performance, anxiety-like behaviors, and hippocampal glial and neurotrophic markers in morphine-withdrawn rats.
Morphine dependence was induced in rats by administering 10 mg/kg morphine for 10 consecutive days, followed by transcutaneous auricular vagus nerve stimulation (taVNS) to the left ear for 2 weeks.
Behavioral outcomes across cognitive and emotional domains were assessed using open field, Y-maze, novel object recognition, and elevated plus maze tests.
Hippocampal expression levels of BDNF, GFAP, and Iba1 were analyzed via quantitative polymerase chain reaction (qPCR).
taVNS significantly reversed morphine-induced deficits in working and recognition memory and exerted anxiolytic effects.
taVNS restored the morphine-induced downregulation of hippocampal BDNF and suppressed elevated GFAP expression levels.
Application of taVNS specifically at a 100 Hz frequency lowered hippocampal Iba1 levels irrespective of prior morphine exposure.

Cite This Study

Nazari et al. (2025) studied this question.

synapsesocial.com/papers/6a838777d71a93cd45e4e603 https://doi.org/10.1111/adb.70016

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Implication

Animal study demonstrates that auricular vagus nerve stimulation restores memory in morphine-withdrawn rats, suggesting a noninvasive adjunct therapy for opioid use disorder.

Transcutaneous Auricular Vagus Nerve Stimulation Restores Cognitive Impairment in Morphine‐Withdrawn Rats: Role of BDNF and Glial Cells in the Hippocampus

Discussion

Member takes

Implication

Key Points

Cite This Study

Transcutaneous Auricular Vagus Nerve Stimulation Restores Cognitive Impairment in Morphine‐Withdrawn Rats: Role of BDNF and Glial Cells in the Hippocampus

Discussion

Member takes

Implication

Key Points

Cite This Study

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