Virus-like particles that tend to be arranged in a crystalline-like pattern have been observed by electron microscopy in as study of suspensions of 5 skin papillomas. Histological examination of the same tissues revealed intranuclear inclusion bodies and characteristic cytoplasmic masses in the cells of the hyperplastic epidermis. Thirty-one lesions with similar histological appearance were encountered along with 158 typical verrucae in a review of surgical pathological material.
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Strauss et al. (1949) studied this question.