What question did this study set out to answer?

To examine the presence of human papillomavirus (HPV) DNA and alterations in the c-myc oncogene in colorectal adenocarcinoma cell lines.

June 1, 1991Diseases of the Colon & Rectum

Human papillomavirus type-related DNA and c- myc oncogene alterations in colon cancer cell lines

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Authors

JCJhy‐Young Cheng CMChing‐Liang MengTri-Service General Hospital CCChung‐Faye ChaoNational Defense Medical Center

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Implication

In vitro analysis demonstrates HPV-16 and HPV-18 DNA alongside c-myc amplification in colon cancer cell lines, suggesting a viral role in colorectal carcinogenesis.

Key Points

To examine the presence of human papillomavirus (HPV) DNA and alterations in the c-myc oncogene in colorectal adenocarcinoma cell lines.
Analyzed three colorectal adenocarcinoma cell lines derived from Chinese patients for papillomavirus expression and specific HPV-16 and HPV-18 DNA sequences.
Assessed c-myc oncogene amplification in the cancer cell lines compared with control tissue.
HPV-16 and HPV-18 DNA sequences were detected across all three colorectal adenocarcinoma cell lines, demonstrating infection in columnar epithelial cells.
c-myc oncogene amplification occurred in all three cancer cell lines, while control tissue displayed only normal germ-line fragments.

Cite This Study

Cheng et al. (1991) studied this question.

synapsesocial.com/papers/6a8387fdb397c5df40cd7dd2 https://doi.org/10.1007/bf02049931

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Implication

In vitro analysis demonstrates HPV-16 and HPV-18 DNA alongside c-myc amplification in colon cancer cell lines, suggesting a viral role in colorectal carcinogenesis.

Human papillomavirus type-related DNA and c- myc oncogene alterations in colon cancer cell lines

Discussion

Member takes

Implication

Key Points

Cite This Study

Human papillomavirus type-related DNA and c- myc oncogene alterations in colon cancer cell lines

Discussion

Member takes

Implication

Key Points

Cite This Study

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