October 12, 2004ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)

Serine 68 phosphorylation of phospholemman: acute isoform-specific activation of cardiac Na/K ATPase

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Population

Isolated guinea pig ventricular myocytes

Comparison

Forskolin (1 micromol/l for 4 min at 35 degrees C) vs Baseline or H89 alone

Design

Preclinical

Authors

BSBernard L. SilvermanOffice of Chief Medical Examiner WFWilliam FullerLangley Research Center PEPhilip EatonQueen Mary University of London

Discussion

Member takes

Implication

Supports PKA-mediated alpha1 NKA activation via phospholemman in animal models; leaves open human translation.

Structured PICO

Population

Isolated guinea pig ventricular myocytes

Intervention

Forskolin (1 micromol/l for 4 min at 35 degrees C)

Comparator

Baseline or H89 (PKA selective inhibitor, 50 micromol/l) alone

Outcome

NKA pump current (I(p)) and its components (I(alpha 1) and I(alpha 2))surrogate

PKA-dependent, alpha 1-specific NKA activation may be mediated through phosphorylation of the accessory protein phospholemman at serine 68, rather than direct alpha1 subunit phosphorylation.

Cite This Study

Silverman et al. (2004) studied this question.

synapsesocial.com/papers/6a83881485b1bf20fffc5428 https://doi.org/10.1016/j.cardiores.2004.09.005

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Serine 68 phosphorylation of phospholemman: acute isoform-specific activation of cardiac Na/K ATPase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Serine 68 phosphorylation of phospholemman: acute isoform-specific activation of cardiac Na/K ATPase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider