August 15, 2023Frontiers in MedicineOpen Access

Whole exome sequencing of well-differentiated liposarcoma and dedifferentiated liposarcoma in older woman: a case report

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Population

A 62-year-old Asian female with progression from WDLPS to DDLPS

Design

Case report

Authors

ZZZidan ZhaoSun Yat-sen University JXJie XuBeijing Tongren Hospital YSYuntao ShiChinese Academy of Medical Sciences & Peking Union Medical College

Discussion

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Implication

Hypothesis-generating for ROS1-targeted therapy in DDLPS; leaves open validation in larger prospective cohorts.

Structured PICO

Population

A 62-year-old Asian female with recurrent retroperitoneal liposarcoma progressing from well-differentiated liposarcoma (WDLPS) to dedifferentiated liposarcoma (DDLPS).

Intervention

Surgical resections followed by targeted therapy (palbociclib, and later combination of palbociclib and crizotinib based on genetic sequencing).

Outcome

Genomic alterations (somatic mutations, copy number variations, and gene fusions) during disease progression from WDLPS to DDLPS.

Whole-exome sequencing of recurrent liposarcoma identified a novel POC1B::ROS1 fusion and highlighted the genomic evolution from WDLPS to DDLPS, suggesting a potential role for targeted combination therapy.

Cite This Study

Zhao et al. (2023) studied this question.

synapsesocial.com/papers/6a838823b59abb3f3b307351 https://doi.org/10.3389/fmed.2023.1237246

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Whole exome sequencing of well-differentiated liposarcoma and dedifferentiated liposarcoma in older woman: a case report

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Whole exome sequencing of well-differentiated liposarcoma and dedifferentiated liposarcoma in older woman: a case report

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider