Mithramycin (1), chromomycin A3, and olivomycin A are structurally related, antitumor agents which belong to the aureolic acid family of antibiotics.1 Considerable research on the synthesis of both the aglycon2-4 and carbohydrate7-9 portions of these molecules naturally has led to interest in methods for joining carbohydrate and aglycon units together.10 One type of coupling which is required for aureolic acid synthesis is that of the A-B disaccharide to the phenolic hydroxyl group at C-6.11 In this communication such a process is described along with a flexible procedure for the formation of the protected A-B disaccharide used in the coupling process.
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Roger W. Binkley (1990) studied this question.
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