Why the study?
Does epicardiectomy reduce myocardial contractile force in a preclinical model?
Does epicardiectomy reduce myocardial contractile force in a preclinical model?
Epicardiectomy decreases myocardial contractile force by disrupting the normal balance of autonomic tonic discharge, specifically releasing the heart from tonic sympathetic control.
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Caution against clinical extrapolation from this animal model; leaves open sympathetic control of contractility in humans.
Kaye et al. (1970) studied this question.
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